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Year : 2019  |  Volume : 12  |  Issue : 2  |  Page : 183-184  

Rosmarinic acid and the most important effects of it on bacteria and signaling pathways of cell

1 Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3 Resident of Infectious and Tropical Diseases, Department of Infectious Diseases, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Date of Web Publication25-Mar-2019

Correspondence Address:
Faeze Sadat Heidari
Shahid Sadoughi University of Medical Sciences, Yazd
Seyed Hossein Shahcheraghi
Infectious Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjdrdypu.mjdrdypu_79_18

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How to cite this article:
Shahcheraghi SH, Ayatollahi J, Lotfi M, Heidari FS, Hemati S. Rosmarinic acid and the most important effects of it on bacteria and signaling pathways of cell. Med J DY Patil Vidyapeeth 2019;12:183-4

How to cite this URL:
Shahcheraghi SH, Ayatollahi J, Lotfi M, Heidari FS, Hemati S. Rosmarinic acid and the most important effects of it on bacteria and signaling pathways of cell. Med J DY Patil Vidyapeeth [serial online] 2019 [cited 2019 Jun 16];12:183-4. Available from: http://www.mjdrdypv.org/text.asp?2019/12/2/183/254782

Dear Editor,

Plants have been utilized for a long time to treat human sicknesses, and it has been assessed that 25% to almost 50% of current drugs are gotten from plants.[1] Ocimum basilicum Lamiaceae (sweet basil) is a member of the family Lamiaceae applied as a kitchen herb and as an ornamental plant.[1] Species of Lamiaceae are valued for their good effects on improvement. Among the different optional metabolites found in most of the Lamiaceae species, rosmarinic acid (RA) is one of the most important caffeic acid esters.[1],[2]

RA is a naturally occurring hydroxylated compound. In view of its pharmaceutical application as cell reinforcement, the majority of the examinations performed on RA have concentrated on understanding its creation and direction, while the natural criticalness of RA in plants has been basically overlooked.[2] Lamiaceae plants were found to have large amounts of phenolics, primarily RA, and in this manner gave great cancer prevention agent and antimicrobial effects.[3] RA decreases the mortality of mice infected with Japanese encephalitis virus.[3] The synergistic effects of RA with antibiotics were observed against Staphylococcus aureus (nonsensitive to methicillin) and methicillin-resistant S. aureus.[3]

RA has an inhibitory impact on proteins of microbial surface recognizing adhesive matrix molecules.[3] Even though RA has been shown to exhibit a synergistic effect with antibiotics, the minimum inhibitory concentration was found to be higher. Therefore, many studies can be done about increasing the efficacy of RA as an additive material for several antibiotics.[3],[4] RA is effective on several cancers, is known as a prevention agent and calming and antimicrobial activities, and helps to avert cell harm caused by free radicals. It initiated apoptosis by adjusting the outflow of different qualities managing apoptosis and holds potential as a subordinate to malignancy chemotherapy.[4]

Antifibrotic impact of carnosic corrosive and RA is because of synergistic genius apoptotic activity on lung fibroblasts and myofibroblasts.[5]

RA can decrease seizure, oxidative stress. It also increases the activity of defensive systems and prevents hippocampal neuronal loss.[6]

Melanogenesis is a physiological procedure that outcomes in the combination of melanin shades, which assume a vital defensive part against skin photocarcinogenesis.[5],[6] RA stimulates melanogenesis through protein kinase A activation signaling.[6]

RA prohibits the cell proliferation stimulated by platelet-derived growth factor (PDGF) or tumor necrosis factor-α, and these effects involved both the G0/G1 and G1/S phases of the cell cycle. RA also decreases the mRNA expressions of PDGF and c-myc in PDGF-stimulated mesangial cells.[7]

Therefore, RA can act as one of the anticancer and antibacterial agents in future researches.

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There are no conflicts of interest.

  References Top

Abedini A, Roumy V, Mahieux S, Biabiany M, Standaert-Vitse A, Rivière C, et al. Rosmarinic acid and its methyl ester as antimicrobial components of the hydromethanolic extract of hyptis atrorubens poit. (Lamiaceae). Evid Based Complement Alternat Med 2013;2013:604536.  Back to cited text no. 1
Bais HP, Walker TS, Stermitz FR, Hufbauer RA, Vivanco JM. Root specific elicitation and antimicrobial activity of rosmarinic acid in hairy root cultures of Ocimum basilicum. Plant Physiol Biochem 2002;40:983-95.  Back to cited text no. 2
Ekambaram SP, Perumal SS, Balakrishnan A, Marappan N, Gajendran SS, Viswanathan V, et al. Antibacterial synergy between rosmarinic acid and antibiotics against methicillin-resistant Staphylococcus aureus. J Intercult Ethnopharmacol 2016;5:358-63.  Back to cited text no. 3
Mekini IG, Skroza D, Ljubenkov I, Imat V, Moina SS, Katalini V. In vitro antioxidant and antibacterial activity of Lamiaceae phenolic extracts: A correlation study. Food Technol Biotechnol 2014;52:119-27.  Back to cited text no. 4
Bahri S, Mies F, Ben Ali R, Mlika M, Jameleddine S, Mc Entee K, et al. Rosmarinic acid potentiates carnosic acid induced apoptosis in lung fibroblasts. PLoS One 2017;12:e0184368.  Back to cited text no. 5
Khamse S, Sadr SS, Roghani M, Hasanzadeh G, Mohammadian M. Rosmarinic acid exerts a neuroprotective effect in the kainate rat model of temporal lobe epilepsy: Underlying mechanisms. Pharm Biol 2015;53:1818-25.  Back to cited text no. 6
Makino T, Ono T, Muso E, Yoshida H, Honda G, Sasayama S, et al. Inhibitory effects of rosmarinic acid on the proliferation of cultured murine mesangial cells. Nephrol Dial Transplant 2000;15:1140-5.  Back to cited text no. 7


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