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ORIGINAL ARTICLE
Year : 2019  |  Volume : 12  |  Issue : 6  |  Page : 511-515

Blood pressure trends in idiopathic steroid-sensitive childhood nephrotic syndrome: A prospective observational study


1 Department of Pediatrics, NRS Medical College, Kolkata, West Bengal, India
2 Department of Pediatrics, Asansol District Hospital, Asansol, West Bengal, India
3 Department of Pediatrics, IPGMER, Kolkata, West Bengal, India

Correspondence Address:
Madhumita Nandi
6/6, Naren Sarkar Road, Kolkata - 700 008, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mjdrdypu.mjdrdypu_262_18

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Background: It has been observed that blood pressure (BP) tends to rise in children with idiopathic nephrotic syndrome (NS) in the acute stage, during attack or relapse, and may reverse back to normal with time. However, there is a lacuna of knowledge regarding the actual trend of BP in these children when they are in medication-free period. The study was conducted to analyze the trend of BP in these children as persistent hypertension (HTN) is an important determinant of future cardiovascular morbidity. Materials and Methods: This was a prospective observational study over 6-month duration in children with diagnosis of idiopathic childhood NS wherein BP recordings were followed up and HTN was managed with medications if required. The secondary causes of HTN and steroid-resistant, steroid-dependent, and frequently relapsing NS were excluded. Results: At initial presentation, 36.4% of children had elevated BP of which 9.0% needed antihypertensive drugs. The corresponding values at remission were 66.6% and 15.15% with a declining trend seen in follow-up. Antihypertensive medications had to be given to 22 (33.33%) children for a mean duration of 30.5 ± 21.8 (range: 7–105) days. There was a significant relation between nadir of serum albumin at the time of attack and number of days to go into remission with incidence of HTN (<0.05). Conclusions: Meticulous tracking of BP is essential in children with idiopathic NS as elevated BP, although to a milder degree, is noted in a significant percentage of these children.


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