|Year : 2020 | Volume
| Issue : 1 | Page : 28-29
Lassa viral hemorrhagic fever
Department of Community Medicine, Dr DY Patil University, Pune, Maharashtra, India; Department of Medical Science, Faculty of Medicine, University of Nis, Nis, Serbia; Department of Biological Science, Joseph Ayobabalola University, Ikeji-Arakeji, Nigeria; Department of Laboratory Medicine, Chulalongkorn University, Bangkok, Thailand
|Date of Submission||28-May-2019|
|Date of Decision||28-May-2019|
|Date of Acceptance||03-Sep-2019|
|Date of Web Publication||16-Dec-2019|
140 Bangkhae, Bangkok 10160
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Wiwanitkit V. Lassa viral hemorrhagic fever. Med J DY Patil Vidyapeeth 2020;13:28-9
Lassa viral hemorrhagic fever presents some interesting features. It is still an important viral infection seen in some specific areas of the world. The report from Nigeria on the disease is a good illustration of this problematic infection. In fact, as a hemorrhagic fever, the disease can present with acute febrile illness and complicated with hemorrhagic complications. Lassa hemorrhagic fever is classified as an important viral hemorrhagic fever. At present, Lassa fever is still an endemic disease in several countries, including Nigeria., The clinical presentation of Lassa fever is similar to several of acute febrile illness, and it usually requires the laboratory investigation for the final diagnosis. The patient might have fever accompanied with other clinical problems such as chest pain and abdominal pain., Furthermore, the hemorrhagic episode might be seen.,
As a vector-borne zoonotic disease, the seasonal variation of the infection might be observable. The main vector of Lassa fever is rodent., Hence, the rodent control is an important primary prevention against Lassa fever. The outbreak might be related to local climatic factors, and it is necessary to understand the local geographical pathology for appropriate planning for disease prevention. Indeed, the seasonal effect on viral hemorrhagic fever is well-defined. The good example is the seasonal variation, with a strong relationship to rainfall in the rainy season, seen in dengue  and Zika virus infection. Nevertheless, Lassa fever is not a mosquito-borne disease but rodent-borne disease. The pattern of seasonal variation is different. In a recent epidemiological survey, the season change of viral prevalence in an important Lassa fever vector – Mastomys natalensis was studied. Fichet-Calvet et al. found that the observed prevalence was higher in the rainy season comparing to summer. However, the risk for human is higher in summer. This is explained by the fact that the existence of rodent vector is more in the house during summer.,,
Compared to another important rodent-related disease – leptospirosis, the difference in peak season of diseases can be seen. In leptospirosis, the peak season is the rainy season. For Lassa fever, the peak season is summer or dry season. This is due to the basic difference of the two diseases. In leptospirosis, the urine is the main infectious source. For Lassa fever, the feces is the main infectious source. During the rainy season, the urine, a body fluid, can easily contaminate floodwaters and cause disease. However, for Lassa fever, it is difficult to detect viral contaminate in food during the rainy season. Based on this specific important data, the surveillance of seasonal prevalence of the virus in rodent vector might not be much useful. A more useful approach would be the surveillance for the existence of the rodent vector in houses.
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