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ORIGINAL ARTICLE
Year : 2021  |  Volume : 14  |  Issue : 1  |  Page : 26-30

To correlate the immunohistochemical analysis of p16 and Ki-67 in oral squamous cell carcinoma with the background of oral submucous fibrosis


Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Vidyapeeth's, Dr. D.Y. Patil Dental College and Hospital, Pune, Maharashtra, India

Correspondence Address:
Roopa Yadahalli
Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Vidyapeeth's, Dr. D.Y. Patil Dental College and Hospital, Pimpri, Pune - 411 018, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mjdrdypu.mjdrdypu_18_20

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Aim: Oral submucous fibrosis (OSF) is a potentially malignant disorder with 7.6% of malignant transformation rate into oral squamous cell carcinoma (OSCC). The aim of the study is to assess the genetic markers p16 and ki-67 in OSF, OSCC, and OSCC with the background of OSF and control group. Materials and Methods: Ten cases of each group were stained with p16 and Ki-67 by immunohistochemistry technique. Results: Statistically significant results were found among the four groups with moderate-to-severe expression (P < 0.05) for Ki-67 and results were negative for p16 in all groups. Conclusion: According to our result, p16 is found not significant marker and Ki-67 can be useful as a proliferative index marker for malignancy development in oral precancerous conditions.


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