|Year : 2021 | Volume
| Issue : 1 | Page : 51
Resistance of Pseudomonas aeruginosa to disinfectants
Rabindranath Nath Misra
Dr. D. Y. Patil Medical College and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India
|Date of Submission||12-Nov-2020|
|Date of Decision||15-Nov-2020|
|Date of Acceptance||19-Nov-2020|
|Date of Web Publication||22-Jan-2021|
Rabindranath Nath Misra
Dr. D. Y. Patil Medical College and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Misra RN. Resistance of Pseudomonas aeruginosa to disinfectants. Med J DY Patil Vidyapeeth 2021;14:51
There are numerous mechanisms harbored by Pseudomonas aeruginosa to resist the action of antibiotics; for example, target-site alteration, decreased penetration, or using enzymes to inactivate the antimicrobial agent. They are categorized as intrinsic or acquired., Biofilm formation by P. aeruginosa is one of the efficient mechanisms by which it resists the action of antibacterial agents in the immediate environment.,, Biofilms are nothing but a biopolymer matrix attached to surfaces such as catheters and plastic tubes. They may also be attached to implantable devices or tissues in cystic fibrosis and osteomyelitis. These biopolymers encase clusters of bacterial colonies and protect them from antibacterial substances.
Biofilm production is controlled by quorum sensing (QS) which is basically cell-to-cell communication by signaling molecules called autoinducers which eventually help in a complex gene regulation process. This QS also controls the expression of virulence factors such as protease, elastase, and exotoxin A besides helping in protection from antibacterial substances.
In one of the studies from Ethiopia, the authors have found resistance of P. aeruginosa to disinfectants such as sodium hypochlorite 0.5% and hydrogen peroxide 3%, albeit a very less percentage. Similar studies have been reported from Brazil and the USA., P. aeruginosa is also seen to develop resistance to 70% ethyl alcohol in 4.8% of isolates and to 2% Savlon in 11.1% of isolates.
The complex genetic makeup and the large genome size of P. aeruginosa reflect adaptability to various ecological niches. It has acquired the capability to efflux antibiotics and other compounds. This is how it has developed intrinsic antibiotic resistance facilitated by low permeability in the outer membrane.
These findings are alarming and do not augur well for the humankind as it is already fighting a losing battle against the multidrug-resistant bacteria, which are resistant to a number of antibiotics. The role of biofilm cannot be underestimated as microenvironment modulation and exchange of genes is facilitated inside the biofilm.
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Conflicts of interest
There are no conflicts of interest.
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