|Year : 2022 | Volume
| Issue : 1 | Page : 121
Antiphospholipid antibody syndrome and dengue fever
Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India; Department of Tropical Medicine, Hainan Medical University, Haikou, China
|Date of Submission||16-Sep-2020|
|Date of Decision||14-Oct-2020|
|Date of Acceptance||16-Nov-2020|
|Date of Web Publication||24-Jun-2021|
Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Wiwanitkit V. Antiphospholipid antibody syndrome and dengue fever. Med J DY Patil Vidyapeeth 2022;15:121
Dengue is an important mosquito-borne infection. This infection is a common tropical disease, and it affects millions of the world population. The disease is an acute febrile illness characterized by high fever with hemorrhagic tendency. The dengue might co-exist with other medical problems, either infectious or noninfectious diseases. The report on catastrophic antiphospholipid antibody syndrome with dengue fever in Med J Dr DY Patil Univ is a good example. In that case, the pathogenesis is interesting, and it might be related to immunopathological process. In fact, catastrophic antiphospholipid syndrome is an important immunological disorder. This immunological disorder is characterized by rapidly progressive widespread thromboses. The thrombotic disorder can affect the microvasculature. The antiphospholipid antibodies are detectable. This immunologic disease can cause multiorgan failure. The patient might have renal failure and respiratory failure. Neurological deterioration is also observable.
Infection is reported for association with catastrophic antiphospholipid syndrome. A variety of infections, including viruses, bacteria, fungi, and parasites, might induce the problem. The molecular mimicry is proposed as the main mechanism. In dengue, molecular mimicry is an important immunopathological process. Hence, it is possible that antiphospholipid syndrome might occur in a dengue patient. Several biomolecules including antibodies, cytokines, hemostatic molecules, and viral proteins are proposed for interrelationship with thrombohemostatic alteration in dengue. Pathophysiologically, transient activation of humoral immunity occurs during dengue infection, and it is a possible immunogenetic induction for coagulopathic thrombosis. This pathobiological process should be the same as that of lupus storm syndrome induced by dengue. As noted by Chen, antiphospholipid antibodies and increased lupus anticoagulant are related to thrombotic events in dengue patients.
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