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Year : 2022  |  Volume : 15  |  Issue : 4  |  Page : 613  

New COVID-19 vaccine, thiomerosol, and reversible cerebral vasoconstriction

1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India

Date of Submission29-May-2021
Date of Decision09-Jul-2021
Date of Acceptance30-Jul-2021
Date of Web Publication07-Mar-2022

Correspondence Address:
Rujittika Mungmunpuntipantip
Private Academic Consultant, Bangkok
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjdrdypu.mjdrdypu_398_21

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How to cite this article:
Mungmunpuntipantip R, Wiwanitkit V. New COVID-19 vaccine, thiomerosol, and reversible cerebral vasoconstriction. Med J DY Patil Vidyapeeth 2022;15:613

How to cite this URL:
Mungmunpuntipantip R, Wiwanitkit V. New COVID-19 vaccine, thiomerosol, and reversible cerebral vasoconstriction. Med J DY Patil Vidyapeeth [serial online] 2022 [cited 2022 Aug 11];15:613. Available from: https://www.mjdrdypv.org/text.asp?2022/15/4/613/339182

Dear Editor,

COVID-19 vaccine is the hope for containment of COVID-19 pandemic. In preventive medicine, the vaccination is the best primary prevention of infectious disease. The new COVID-19 vaccine usually receives a registration certificate under emergency rules adopted during the COVID-19 pandemic, and there are limited data on efficacy and adverse effect of the new vaccine. Different COVID-19 vaccines might have different efficacies and adverse effects.

Focusing on the possible adverse effect of COVID-19 vaccine, there are some reports on neurological problems after COVID-19 vaccination. A reversible cerebral vasoconstriction might be observed in some persons receiving inactivated COVID-19 vaccine. The reversible cerebral vasoconstriction is a rare adverse effect of some vaccines such as measles vaccine.[1] For a noninactivated COVID-19 vaccine, it might induce viscosity change and result in a thrombohemostatic disorder.[2] Coagulation risk with the adenoviral vector vaccines is also related to induction of antibody to platelet factor 4.[3] Nevertheless, the pathogenesis of neurological deficit due to inactivated COVID-19 vaccine is unknown.

Regarding the adverse effect due to COVID-19 vaccine, a component of the vaccine might play an important role. In a recent study, the component of COVID-19 vaccine is associated with an allergic adverse effect.[4] Regarding inactivated vaccine, thimerosal is a component that might be related to adverse effect. Thimerosal is a mercury compound used as a composition of inactivated COVID-19 vaccine. It can cause allergic-like reaction at skin.[5] The vasoconstriction effect of thimerosal is also reported,[6] and it might be associated with reversible cerebral vasoconstriction after inactivated COVID-19 vaccination. Further studies on this issue are recommended.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Hamano T, Takeda T, Morita H, Muramatsu T, Yoneda M, Kimura H, et al. Posterior reversible encephalopathy syndrome following measles vaccination. J Neurol Sci 2010;298:124-6.  Back to cited text no. 1
Wiwanitkit V. COVID-19 Vaccine, Immune Response, Previous Asymptomatic Infection and Blood Clots. Available from: https://www.bmj.com/content/372/bmj.n699/rr-2. [Last accessed on 2021 Jul 01].  Back to cited text no. 2
Geeraerts T, Montastruc F, Bonneville F, Mémier V, Raposo N, Toulouse Vitt Study Group. Oxford-AstraZeneca COVID-19 vaccine-induced cerebral venous thrombosis and thrombocytopaenia: A missed opportunity for a rapid return of experience. Anaesth Crit Care Pain Med 2021;40:100889.  Back to cited text no. 3
Kounis NG, Koniari I, de Gregorio C, Velissaris D, Petalas K, Brinia A, et al. Allergic reactions to current available COVID-19 vaccinations: Pathophysiology, causality, and therapeutic considerations. Vaccines (Basel) 2021;9:221.  Back to cited text no. 4
Peng B, Che D, Hao Y, Zheng Y, Liu R, Qian Y, et al. Thimerosal induces skin pseudo-allergic reaction via Mas-related G-protein coupled receptor B2. J Dermatol Sci 2019;95:99-106.  Back to cited text no. 5
Lemos NB, Angeli JK, Faria Tde O, Ribeiro Junior RF, Vassallo DV, Padilha AS, et al. Low mercury concentration produces vasoconstriction, decreases nitric oxide bioavailability and increases oxidative stress in rat conductance artery. PLoS One 2012;7:e49005.  Back to cited text no. 6


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