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LETTER TO THE EDITOR
Year : 2022  |  Volume : 15  |  Issue : 6  |  Page : 953  

Thyroid profile in idiopathic childhood steroid-sensitive nephrotic syndrome


Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Submission24-Dec-2021
Date of Decision10-Feb-2022
Date of Acceptance21-Mar-2022
Date of Web Publication01-Jun-2022

Correspondence Address:
Prof. Mahmood D Al-Mendalawi
P.O. Box 55302, Baghdad Post Office, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mjdrdypu.mjdrdypu_1022_21

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How to cite this article:
Al-Mendalawi MD. Thyroid profile in idiopathic childhood steroid-sensitive nephrotic syndrome. Med J DY Patil Vidyapeeth 2022;15:953

How to cite this URL:
Al-Mendalawi MD. Thyroid profile in idiopathic childhood steroid-sensitive nephrotic syndrome. Med J DY Patil Vidyapeeth [serial online] 2022 [cited 2023 Jan 30];15:953. Available from: https://www.mjdrdypv.org/text.asp?2022/15/6/953/346441



Sir,

In the November-December 2021 issue of the Medical Journal of Dr. D.Y. Patil Vidyapeeth, Nandi et al.[1] studied thyroid status in a cohort of Indian children with steroid-sensitive nephrotic syndrome (NS) during the time of relapse and remission. They found that the levels of thyroid stimulating-hormone (TSH), triiodothyronine (T3), and thyroxine (T4) significantly varied at the attack/relapse compared to at remission. While T3 and T4 levels stayed within the normal ranges, there was a rise in the TSH level at the time of the attack/relapse.[1] Apart from the few study limitations presented by Nandi et al.,[1] we believe that the following limitation is relevant. The accurate evaluation of thyroid gland functions for a given pediatric population requires the need to refer to the thyroid hormones normative values (THNV). As THNV are determined by different factors such as age, gender, weight, and ethnicity,[2] certain pediatric populations-specific THNV have been generated.[3],[4] India has already constructed THNV for each year of life for both genders separately to be utilized in the clinical fields and researches centers.[5] In the study, methodology, Nandi et al.[1] regrettably did not address which THNV they referred to assess thyroid condition in the studied cohort. This methodological limitation might throw further suspicions on the study findings.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Nandi M, Basu B, Tarai A, Sar T. Thyroid profile in idiopathic childhood steroid-sensitive nephrotic syndrome. Med J DY Patil Vidyapeeth 2021;14:637-41.  Back to cited text no. 1
  [Full text]  
2.
Önsesveren I, Barjaktarovic M, Chaker L, de Rijke YB, Jaddoe VWV, van Santen HM, et al. Childhood thyroid function reference ranges and determinants: A literature overview and a prospective cohort study. Thyroid 2017;27:1360-9.  Back to cited text no. 2
    
3.
Gunapalasingham G, Frithioff-Bøjsøe C, Lund MAV, Hedley PL, Fonvig CE, Dahl M, et al. Reference values for fasting serum concentrations of thyroid-stimulating hormone and thyroid hormones in healthy Danish/North-European white children and adolescents. Scand J Clin Lab Invest 2019;79:129-35.  Back to cited text no. 3
    
4.
Argente Del Castillo P, Pastor García MI, Morell-Garcia D, Martinez-Gomez L, Ballesteros MA, Barcelo A. Thyroid panel reference intervals in healthy children and adolescents: A Spanish cohort. Clin Biochem 2021;91:39-44.  Back to cited text no. 4
    
5.
Marwaha RK, Tandon N, Desai AK, Kanwar R, Aggarwal R, Sastry A, et al. Reference range of thyroid hormones in healthy school-age children: Country-wide data from India. Clin Biochem 2010;43:51-6.  Back to cited text no. 5
    




 

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