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| LETTER TO THE EDITOR |
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| Year : 2022 | Volume
: 15
| Issue : 6 | Page : 953 |
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Thyroid profile in idiopathic childhood steroid-sensitive nephrotic syndrome
Mahmood D Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
| Date of Submission | 24-Dec-2021 |
| Date of Decision | 10-Feb-2022 |
| Date of Acceptance | 21-Mar-2022 |
| Date of Web Publication | 01-Jun-2022 |
Correspondence Address:
Prof. Mahmood D Al-Mendalawi
P.O. Box 55302, Baghdad Post Office, Baghdad
Iraq
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/mjdrdypu.mjdrdypu_1022_21
How to cite this article:
Al-Mendalawi MD. Thyroid profile in idiopathic childhood steroid-sensitive nephrotic syndrome. Med J DY Patil Vidyapeeth 2022;15:953 |
Sir,
In the November-December 2021 issue of the Medical Journal of Dr. D.Y. Patil Vidyapeeth, Nandi et al.[1] studied thyroid status in a cohort of Indian children with steroid-sensitive nephrotic syndrome (NS) during the time of relapse and remission. They found that the levels of thyroid stimulating-hormone (TSH), triiodothyronine (T3), and thyroxine (T4) significantly varied at the attack/relapse compared to at remission. While T3 and T4 levels stayed within the normal ranges, there was a rise in the TSH level at the time of the attack/relapse.[1] Apart from the few study limitations presented by Nandi et al.,[1] we believe that the following limitation is relevant. The accurate evaluation of thyroid gland functions for a given pediatric population requires the need to refer to the thyroid hormones normative values (THNV). As THNV are determined by different factors such as age, gender, weight, and ethnicity,[2] certain pediatric populations-specific THNV have been generated.[3],[4] India has already constructed THNV for each year of life for both genders separately to be utilized in the clinical fields and researches centers.[5] In the study, methodology, Nandi et al.[1] regrettably did not address which THNV they referred to assess thyroid condition in the studied cohort. This methodological limitation might throw further suspicions on the study findings.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
| References | |  |
| 1. | Nandi M, Basu B, Tarai A, Sar T. Thyroid profile in idiopathic childhood steroid-sensitive nephrotic syndrome. Med J DY Patil Vidyapeeth 2021;14:637-41.  [Full text] |
| 2. | Önsesveren I, Barjaktarovic M, Chaker L, de Rijke YB, Jaddoe VWV, van Santen HM, et al. Childhood thyroid function reference ranges and determinants: A literature overview and a prospective cohort study. Thyroid 2017;27:1360-9. |
| 3. | Gunapalasingham G, Frithioff-Bøjsøe C, Lund MAV, Hedley PL, Fonvig CE, Dahl M, et al. Reference values for fasting serum concentrations of thyroid-stimulating hormone and thyroid hormones in healthy Danish/North-European white children and adolescents. Scand J Clin Lab Invest 2019;79:129-35. |
| 4. | Argente Del Castillo P, Pastor García MI, Morell-Garcia D, Martinez-Gomez L, Ballesteros MA, Barcelo A. Thyroid panel reference intervals in healthy children and adolescents: A Spanish cohort. Clin Biochem 2021;91:39-44. |
| 5. | Marwaha RK, Tandon N, Desai AK, Kanwar R, Aggarwal R, Sastry A, et al. Reference range of thyroid hormones in healthy school-age children: Country-wide data from India. Clin Biochem 2010;43:51-6. |
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