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Etiology of primary amenorrhea: Experience from a tertiary care hospital in Western India


1 Department of Obstetrics and Gynaecology, Armed Forces Medical College, Pune, Maharashtra, India
2 Department of Obstetrics & Gynaecology, Command Hospital (AF), Bengaluru, Karnataka, India

Correspondence Address:
Rajesh Kumar Mishra,
Department of Obstetrics and Gynaecology, Armed Forces Medical College, Golden Jubilee Block, Solapur Road, Pune - 411 040, Maharashtra
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjdrdypu.mjdrdypu_395_20

Objectives: The etiology of primary amenorrhea is varied and can involve different organ systems. Gonadal dysgenesis and Mullerian agenesis are two most common disorders contributing to it. However, there is no consensus about the prevalence of different etiologies among studies reported from different parts of the world. The present study was carried out to evaluate different etiological factors responsible for primary amenorrhea in Western India. Materials and Methods: This was a prospective observational study carried out at a tertiary care hospital in Maharashtra. Thirty cases of primary amenorrhea were evaluated over a period of 2 years and data were analyzed regarding etiology and various management options. Results: Fourteen out of 30 cases had Mullerian agenesis and gonadal dysgenesis was reported in five cases. No case of genital tuberculosis was reported in our study. Most cases of Mullerian agenesis were managed with vaginoplasty, whereas cases of gonadal dysgenesis were managed with cyclical hormonal therapy. Conclusion: Mullerian agenesis was the most common etiology of primary amenorrhea followed by gonadal dysgenesis in our study. Diagnosis of patients of amenorrhea should be meticulous and their management depends on the underlying etiology.


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    -  Mishra RK
    -  Kohli UA
    -  Seth A
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