Medical Journal of Dr. D.Y. Patil Vidyapeeth

: 2021  |  Volume : 14  |  Issue : 1  |  Page : 13-

Vitamin D, antiviral agent, and COVID-19

Viroj Wiwanitkit 
 Depatment of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India; Department of Tropical Medicine, Hainan Medical University, Haikou, China

Correspondence Address:
Viroj Wiwanitkit
Depatment of Community Medicine, Dr. DY Patil University, Pune, Maharashtra

How to cite this article:
Wiwanitkit V. Vitamin D, antiviral agent, and COVID-19.Med J DY Patil Vidyapeeth 2021;14:13-13

How to cite this URL:
Wiwanitkit V. Vitamin D, antiviral agent, and COVID-19. Med J DY Patil Vidyapeeth [serial online] 2021 [cited 2021 Mar 3 ];14:13-13
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Full Text

Vitamin is a necessary trace element for human beings. Human requires a few amount of vitamin, but it has to be intake. The role of vitamin in homeostasis and regulations of the physiological process in the human bond is important. In clinical nutrition, several advantages of vitamin are purposed. The role of vitamin in infectious disease management is very interesting. Vitamin plays might play a role in infectious disease management by both direct and infect mechanisms. The publication in the journal on “Vitamin D as an Antiviral Agent” is interesting.[1] According to the present new emerging coronavirus crisis, medical scientists have tried best to find the alternative new therapy for disease containment since its first emergence.

Vitamin is an alternative that is mentioned. Of several vitamins, Vitamin D is widely proposed for its usefulness. Basically, Vitamin D is a nonwater soluble vitamin and biosynthesis after sunlight exposure is possible in the human body. A good example is a recent report on the immunomodulation effect for the treatment of epidemic diarrheal virus infection in the animal model.[2] Regarding the new emerging COVID-19, there is still no clinical trial on the therapeutic/preventive effect of Vitamin D. There are some observational reports on the clinical association. In a recent report from the UK, low Vitamin D status was associated with the risk of severe COVID-19.[3] It is proposed that Vitamin D deficiency might increase the severity of COVID-19.[4]

Based on the mentioned observations, some medical scientists believe that Vitamin D might be an alternative drug for the management of COVID-19. Vitamin D receptor stimulation is believed to be an important pharmacophysiological process of Vitamin D that might be beneficial for the management of COVID-19.[5] Nevertheless, the role of Vitamin D receptor and its genetic polymorphisms in vitamin-related mechanisms for the management of the infectious disease is still unknown at present. There are also confounding factors that it can still not conclude for the exact association between Vitamin D and COVID-19.[3] The high incidence of COVID-19 is still reported from tropical countries where there is no problem of Vitamin D deficiency among the local population.[6] Since there is still no standard treatment or vaccine for the management of COVID-19, the use of Vitamin D for COVID-19 management, which is a nutrition, might be an interesting clinical research issue.


1Ghosh J. Vitamin D as an antiviral agent. Med J Dr DY Patil Univ 2021;14:3-12.
2Yang J, Tian G, Chen D, Zheng P, Yu J, Mao X, et al. Dietary 25-Hydroxyvitamin D 3 supplementation alleviates porcine epidemic diarrhea virus infection by improving intestinal structure and immune response in weaned pigs. Animals (Basel) 2019;9:627.
3Raisi-Estabragh Z, McCracken C, Bethell MS, Cooper J, Cooper C, Caulfield MJ, et al. Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: Study of 1326 cases from the UK Biobank. J Public Health (Oxf) 2020;42:451-460.:fdaa095.
4Weir EK, Thenappan T, Bhargava M, Chen Y. Does vitamin D deficiency increase the severity of COVID-19? Clin Med (Lond) 2020;20:e107-e108.
5Quesada-Gomez JM, Castillo ME, Bouillon R. Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections: Revised Ms SBMB 2020_166. J Steroid Biochem Mol Biol 2020;202:105719.
6Ribeiro H, Santana KV, Oliver SL, Rondó PH, Mendes MM, Charlton K, et al. Does Vitamin D play a role in the management of COVID-19 in Brazil? Rev Saude Publica 2020;54:53.