Medical Journal of Dr. D.Y. Patil Vidyapeeth

: 2021  |  Volume : 14  |  Issue : 1  |  Page : 3--12

Potential role of Vitamin D as an antiviral agent

Joyeta Ghosh 
 Department of Dietetics and Nutrition, NSHM Knowledge Campus, Maulana Abul Kalam Azad University of Technology, West Bengal, India

Correspondence Address:
Joyeta Ghosh
Department of Dietetics and Nutrition, NSHM Knowledge Campus, MAKAUT, Kolkata, West Bengal

Vitamin D has potential antimicrobial activity, the deficiency of which has deleterious effects on the general well-being and longevity, predisposing major public health problem worldwide. About 1 billion people have Vitamin D deficiency, which is prevalent among all ethnicities and age groups throughout the world. In addition, the incidence of antimicrobial resistance has emerged as a major threat to public health, and it is estimated to cause 10 million deaths annually by 2050 throughout the world. Vitamin D, as a mighty antimicrobial agent, may decrease the occurrence of infection through numerous pathways. Vitamin D strengthens innate immunity by modulating the production of various anti-microbial peptide (AMPs), cytokine, chemokines and interleukin responses. Vitamin D is responsible for the regulation of >200 genes, including cell proliferation, differentiation, and apoptotic genes. It acts as the key holder for modulating systemic inflammation, oxidative stress, and mitochondrial respiratory functions. Thus, a Vitamin D replete state appears to benefit most infections. As an antiviral agent, Vitamin D may constitute an inexpensive prophylactic option either by itself or as a synergistic agent during the treatment of different viral infections. The present review stipulates the importance of Vitamin D and its possible mechanisms against treating any kind of viruses. Relevant published articles were summarized by performing computerized literature searches (searches were made in PubMed/Medline, EMBASE, ScienceDirect, and Scirus) of different authentic databases using the following keywords: Vitamin D, VDR, infections, antimicrobial peptides, viruses, and COVID-19. The future for the sunshine vitamin as an antiviral agent looks brighter. More scientific proposition entailing in vitro, in vivo, or genomic studies are required to understand how important Vitamin D is against viral infections.

How to cite this article:
Ghosh J. Potential role of Vitamin D as an antiviral agent.Med J DY Patil Vidyapeeth 2021;14:3-12

How to cite this URL:
Ghosh J. Potential role of Vitamin D as an antiviral agent. Med J DY Patil Vidyapeeth [serial online] 2021 [cited 2021 Feb 28 ];14:3-12
Available from:;year=2021;volume=14;issue=1;spage=3;epage=12;aulast=Ghosh;type=0